- Cheapest oneway flight
- from€276
- Cheapest roundtrip flight
- from€599
- Fastest flight
- non-stop flights
- 2x / week
- Flight distance
- 8,928 km
- Time difference
- Most popular airlines
- Air Europa Lineas Aereas
- Boliviana de Aviacion
- Air Europa Lineas Aereas
Flight schedule from Madrid (MAD) to Santa Cruz (VVI)
Select a travel date in the flight schedule for the route from Madrid (MAD) to Santa Cruz (VVI) and compare affordable flight deals.
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Matching outbound flightsMAD–VVI · 13 of 13
fromto
dep.arr.
durationstopovers
- 26 Oct – 1 Nov 2026
- 2 – 8 November 2026
- 9 – 15 November 2026
- MADVVI1 stopover
- MADVVInon-stop
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVInon-stop
- MADVVInon-stop
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVInon-stop
Important flight information
Frequently Asked Questions (FAQ)
How long is the flight from Madrid to Santa Cruz?
A direct flight from Madrid to Santa Cruz typically takes around 10 hours. If you choose a connecting flight, you should allow more time. Typical one-stop journeys take around 25 hours 30 minutes. For the quickest journey, a direct flight is usually the most comfortable choice.
Are there direct flights from Madrid to Santa Cruz?
Yes, there are direct flights from Madrid to Santa Cruz, although not necessarily every day. On average, around 2 to 3 flights per week are available. If you have flexibility with your travel dates, you will find it easier to secure a suitable direct connection.
Which airlines fly from Madrid to Santa Cruz?
Direct flights from Madrid to Santa Cruz are operated by, among others, Boliviana de Aviacion and Air Europa. These services take you to Santa Cruz without any stops, making them particularly handy for short breaks or weekend trips. It is still worth comparing departure times and airline policies, as baggage rules and additional charges can vary.
On which days are there direct flights from Madrid to Santa Cruz?
Direct flights from Madrid to Santa Cruz operate daily. The schedule may vary by season, so it is worth comparing several travel dates. If your preferred day has no direct service, nearby departure days or short connecting flights may be a good alternative.
How many flights are there per day from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz there is less than one flight per day on average. The exact number can vary by day of the week and season. If you have flexibility with your travel dates, it is worth comparing several departure days.
How many flights per week are there from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz there are only a few flights per week. It is therefore especially worthwhile to be flexible with your travel dates so you can more easily find a suitable departure day.
When does the first flight from Madrid to Santa Cruz depart?
The earliest direct flight from Madrid to Santa Cruz usually departs at 02:50. The exact departure time may vary by day of the week and airline. Early flights are particularly useful if you want to make the most of your arrival day in Santa Cruz.
When does the last flight from Madrid to Santa Cruz depart?
The last direct flight from Madrid to Santa Cruz usually departs at 23:35. Late flights can be convenient if you want to travel after work or in the evening. Do check whether it is a direct flight, as a connecting service could push the arrival time significantly later.