- Fastest flight
- non-stop flights
- 3x / week
- Flight distance
- 8,928 km
- Time difference
- Most popular airlines
- Air Europa Lineas Aereas
- Boliviana de Aviacion
- Air Europa Lineas Aereas
Flight schedule from Madrid (MAD) to Santa Cruz (VVI)
Select a travel date in the flight schedule for the route from Madrid (MAD) to Santa Cruz (VVI) and compare affordable flight deals.
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Matching outbound flightsMAD–VVI · 10 of 10
fromto
dep.arr.
durationstopovers
- 14 – 20 September 2026
- 21 – 27 September 2026
- 28 Sept – 4 Oct 2026
- MADVVI1 stopover
- MADVVInon-stop
- MADVVI1 stopover
- MADVVInon-stop
- MADVVInon-stop
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVI1 stopover
- MADVVInon-stop
- MADVVI1 stopover
Important flight information
Frequently Asked Questions (FAQ)
How long is the flight from Madrid to Santa Cruz?
A direct flight from Madrid to Santa Cruz typically takes around 11 hours 20 minutes. If you choose a connecting flight, you should allow more time. Typical one-stop journeys take around 20 hours 45 minutes. For the quickest journey, a direct flight is usually the most comfortable choice.
Are there direct flights from Madrid to Santa Cruz?
Yes, there are direct flights from Madrid to Santa Cruz, although not necessarily every day. On average, around 3 to 4 flights per week are available. If you have flexibility with your travel dates, you will find it easier to secure a suitable direct connection.
Which airlines fly from Madrid to Santa Cruz?
Direct flights from Madrid to Santa Cruz are operated by, among others, Air Europa and Boliviana de Aviacion. There are also connecting flights with one stop, for example with Avianca (via Bogota), Aerolineas Argentinas (via Buenos Aires-Ezeiza) and LATAM Chile (via Lima). If a short travel time matters to you, a direct flight is usually the most convenient option. Connecting flights often give you more choice of departure times and airlines.
On which days are there direct flights from Madrid to Santa Cruz?
Direct flights from Madrid to Santa Cruz operate Monday, Wednesday, Friday, Saturday and Sunday. The schedule may vary by season, so it is worth comparing several travel dates. If your preferred day has no direct service, nearby departure days or short connecting flights may be a good alternative.
How many flights are there per day from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz there is less than one flight per day on average. The exact number can vary by day of the week and season. If you have flexibility with your travel dates, it is worth comparing several departure days.
How many flights per week are there from Madrid to Santa Cruz?
On the route from Madrid to Santa Cruz there are around 3 to 4 flights per week. The number of services can vary depending on the season and day of the week. If you have flexibility, it is worth looking at several departure days to find the best option.
When does the first flight from Madrid to Santa Cruz depart?
The earliest direct flight from Madrid to Santa Cruz usually departs at 03:05. The exact departure time may vary by day of the week and airline. Early flights are particularly useful if you want to make the most of your arrival day in Santa Cruz.
When does the last flight from Madrid to Santa Cruz depart?
The last direct flight from Madrid to Santa Cruz usually departs at 23:35. Late flights can be convenient if you want to travel after work or in the evening. Do check whether it is a direct flight, as a connecting service could push the arrival time significantly later.